<h1>Observatory of Coronavirus Clinical Trials</h1>
<h1>Observatory of Coronavirus Clinical Trials</h1>
Last update : April 8 2020.
<h3>Main goals</h3>
<h3>Main goals</h3>
<p>Several hundred clinical trials on COVID-19 were launched within a few weeks worldwide. Planned/ongoing/terminated trials are being tracked by WHO and physicians.</p>
<p>The provision of a synthetic view of these clinical trials is essential for the coordination of the research community: to explore new therapeutic targets while avoiding similar studies.<p>
<p>This is the objective of this mapping which, based on textual data mining of the metadata of these trials, allows to see at a glance all the avenues explored by current and past clinical trials, the combinations of treatments, their main categories and the expected or observed results.<p>
<p>What you see are the main categories of treatments and outcomes and for each of them, the most related treatments and outcomes are highlighted. Two terms are linked on the map if there is a statistical relation in the set of clinical trials between them.</p>
<h3>Four maps are available</h3>
<h3>Four maps are available</h3>
You can select one of four maps :
<ul>
<li> Two maps based on the analysis of the treatment description alone, and two based on the analysis of the treatment and outcomes description,
<li> For each case, links can represent two different proximity measures (see below).
</ul>
<h3>Details</h3>
<h3>Details</h3>
<p>These maps are based on database of randomized COVID studies provided by the WHO and pre-processed by an <ahref="https://covid-nma.com/"target="blank">international collaboration of laboratories</a> that filter, clean, enrich the dataset. We got it from <ahref="http://www.mastercer.com/home/professors/professor-boutron/"target="blank">Pr Isabelle Boutron</a> (CRESS-UMR1153) on April 8 2020. The aim of this database is to inform about current studies and explore new therapeutic targets, avoiding similar studies. It synthetises more than 600 clinical trials arms on coronavirus. </p>
<p>These studies are all pre-recorded and therefore normally ethically validated; however, some have not yet begun. <br/>As of April 8 2020, a total of 274 studies have been recorded. This database is a manual work so there may be some inconsistencies, it has been enriched with the treatment families.</p>
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<p><b>In the Conditional map</b>, links between terms represent the conditionnal probability of having one terms knowing the other in a paper (its the confidence measure).</p>
<p>In each graph, the node size is a fonction of the pagerank of the term in the graph.</p>
<p>The mathematical formula of these proximity measure can be found in the <ahref="https://iscpif.fr/gargantext/mesures-utilisees-dans-gargantext/"target="blank">Gargantext documentation.</a>
<h4>Warning</h4>
<p>This map uses a CNRS open source tool that has been diverted from its original use for visualization examples (<ahref="https://github.com/moma/ProjectExplorer">ProjectExplorer</a>). The display of documents associated with a selection on the map has a few bugs that we will try to correct if this way of presenting clinical trials proves useful for researchers and practitioners working on coronavirus.</p>
<h4>More about these maps</h4>
Please contact <ahref="http://chavalarias.org"target="blank">David Chavalarias</a>, CNRS, Complex Systems Institute of Paris Île-de-France.